ERa-Dependent E2F Transcription Can Mediate Resistance to Estrogen Deprivation in Human Breast Cancer
نویسندگان
چکیده
Authors' Affiliations: Departments of Cancer Biology, Medicine, Biostatistics, Radiology and Radiological Sciences, and Pathology; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center; Institute of Imaging Sciences, Vanderbilt University, Nashville, Tennessee; Breakthrough Breast Cancer Centre, Institute of Cancer Research, and Academic Department of Biochemistry, Royal Marsden Hospital, London, UK; Novartis Institute for Biomedical Research, Oncology Disease Area, Basel, Switzerland; Departments of Breast Medical Oncology and Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas; Breast Research Group, University of Edinburgh, Edinburgh, UK Note: Supplementary data for this article are available at Cancer Discovery Online (http://www.cancerdiscovery.aacrjournals.org).
منابع مشابه
ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer.
Most estrogen receptor α (ER)-positive breast cancers initially respond to antiestrogens, but many eventually become estrogen-independent and recur. We identified an estrogen-independent role for ER and the CDK4/Rb/E2F transcriptional axis in the hormone-independent growth of breast cancer cells. ER downregulation with fulvestrant or small interfering RNA (siRNA) inhibited estrogen-independent ...
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